Abstract In this work, an in silico study and evaluation of the cytotoxicity of 4-(4-chlorophenyl)thiazole compounds against mouse splenocytes and the chloroquine-sensitive Plasmodium falciparum 3D7 strain are reported. The in silico results showed that the compounds have important pharmacokinetic properties for compounds with potential drug candidates. Regarding cytotoxicity assays against splenocytes, the compounds have low cytotoxicity. In addition, they were able to promote activation of these cells by increasing nitric oxide production without promoting cell death. Finally, they were able to promote cell proliferation. Regarding the in vitro anti-P. falciparum activity assays, it was observed that the compounds were able to inhibit the parasite’s growth, presenting IC50 values ranging from 0.79 to greater than 10 µM. These results are promising when compared to chloroquine. Therefore, this study showed that 4-(4-chlorophenyl)thiazole compounds are promising candidates for antimalarials.

Ever increasing multi-drug resistance by Plasmodium falciparum is creating new challenges in malaria chemotherapy. In the absence of licensed vaccines, treatment and prevention of malaria is heavily dependent on drugs. Potency, range of activity, safety, low cost and ease of administration are crucial issues in the design and formulation of antimalarials. We have tested three synthetic ozonides NAC89, LC50 and LCD67 in vitro and in vivo against multidrug resistant Plasmodium. In vitro, LC50 was at least 10 times more efficient inhibiting P. falciparum multidrug resistant Dd2 strain than chloroquine and mefloquine and as efficient as artemisinin (ART), artesunate and dihydroartemisinin. All three ozonides showed high efficacy in clearing parasitaemia in mice, caused by multi-drug resistant Plasmodium chabaudi strains, by subcutaneous administration, demonstrating high efficacy in vivo against ART and artesunate resistant parasites.

This paper studies two convergent yet contrasting temporalities in “El sueño de Rapiña” by Carlos Reyles. The first one, related to sensuality and hedonism, seeks a return to an ontological past in order to recover an existing unity between man and nature. The second one is based on the correspondence between a capitalist economy and time, which promoted an excessive faith in the future. The analysis also examines Reyles’ harsh criticism to a materialism originated by modern economic models with the resulting nostalgia of a lost humanism.

Este estudio examina dos temporalidades contrastantes y confluyentes en este texto de Carlos Reyles. Una que relacionada al hedonismo y lo sensual busca volver a un pasado ontológico para recuperar la unidad existente entre el hombre y la naturaleza y otra que, basada en la correspondencia entre la economía capitalista y el tiempo, promovía una fe desmedida en el futuro. Se examina, asimismo, la crítica de Reyles al materialismo gestado por los modelos económicos modernos con la consiguiente nostalgia de un humanismo perdido.